Senior Manager - HR Business Partner

At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives.

We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting-edge molecular science and AI, we ask ourselves every day: “What would I do if this patient were my mom?” That question drives everything we do.

But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose.

Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins.

Position Summary

The Senior Manager, HR Business Partner supports Caris Life Sciences’ commercial, clinical, or corporate functions by delivering high-quality HR partnership and executing people strategies that enable business performance and growth.

This role translates enterprise HR strategy into effective, business-aligned execution, with a focus on employee relations, talent processes, and organizational effectiveness within assigned client groups.

Job Responsibilities

• Serve as the primary HR partner to Director and Senior Director level leaders within assigned functions.
• May have direct supervisory responsibilities, including coaching, performance management, and development of HR team members or HRBP associates, as assigned.
• Execute HR strategies and programs that support business objectives, workforce needs, and employee engagement.
• Provide day-to-day employee relations support, including investigations, conflict resolution, and performance management guidance.
• Coach managers on performance management, feedback, team effectiveness, and employee development.
• Support execution of talent processes, including performance reviews, talent calibration, and succession planning at the functional level.
• Partner with business leaders on workforce planning, including headcount management and organizational changes within teams.
• Support implementation of organizational design changes, including restructures and role clarity efforts.
• Partner with Total Rewards to execute compensation programs, including incentive plans for commercial teams.
• Support rollout of HR programs such as engagement surveys, performance management cycles, and compensation reviews.
• Collaborate with HR Centers of Excellence (Talent Acquisition, Total Rewards, Learning & Development) to deliver integrated HR solutions.
• Utilize HR data and dashboards to monitor trends and provide basic insights to business leaders.
• Promote a high-performance, mission-driven culture aligned with Caris Life Sciences’ focus on improving patient outcomes.

Required Qualifications

• Bachelor’s degree in human resources, Business Administration, or related field.8+ years of progressive Human Resources experience, including HRBP or generalist experience.5+ years of experience in a supervisory role with Human Resources.
• Experience supporting commercial, sales, clinical, or other fast-paced business functions.
• Demonstrated experience in employee relations, performance management, and manager coaching.
• Ability to execute HR programs effectively in a dynamic, high-growth environment.
• Strong interpersonal, communication, and problem-solving skills.
• Proficient in Microsoft Office Suite, specifically Word, Excel, Outlook, and general working knowledge of Internet for business use.

Preferred Qualifications

• Experience in life sciences, diagnostics, biotechnology, or healthcare environments.
• Experience supporting geographically dispersed or field-based teams.HR certification (SHRM-CP, PHR).
• Experience with Workday or similar HRIS systems.

Physical Demands

Ability to remain in a stationary position for extended periods of time.

Ability to operate a computer and other office equipment.

Occasional ability to move or lift up to 15 pounds.

TrainingAll job specific, safety, and compliance training are assigned based on the job functions associated with this employee.

OtherThis position requires periodic travel to support business leaders and team engagement.

At times may require work outside standard business hours to support business needs and geographically dispersed teams.

Conditions of Employment: Individual must successfully complete pre-employment process, which includes criminal background check, drug screening, credit check ( applicable for certain positions) and reference verification.

This job description reflects management’s assignment of essential functions. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

Caris Life Sciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender, gender identity, sexual orientation, age, status as a protected veteran, among other things, or status as a qualified individual with disability.