Who We Are
Osanni Bio is a development-stage therapeutics platform, headquartered in San Francisco, California. We are creative and agile innovators, relentlessly curious about finding new ways to target the biology behind diseases with the greatest unmet need and determined to do something about it.
At the center of Osanni is its innovation engine, which is optimized for discovering new scientific insights, designing novel drug concepts, and efficiently advancing programs to a meaningful proof-of-concept. Once a program is sufficiently de-risked, it graduates into its ecosystem of affiliate companies, which are equipped with the dedicated focus, specialized talent and support necessary to scale.
Osanni’s architecture marries the scientific depth and operational power of a centralized platform with the speed, agility and accountability of independent companies. The result: an opportunity to create and deliver more transformative medicines.
We hold patients and the physicians who care for them as our North Star. It guides our purpose, sharpens our decision-making, and defines our impact. Osanni is currently advancing programs in ophthalmology, cardiology and beyond. We are building a highly skilled team, passionate about having an impact on human health.
Be part of creating an organization where people enjoy their work and their colleagues, are valued for their individuality, and can't imagine working anywhere else.
About the Role
The Director, HR is responsible for leading the day-to-day operations of the Human Resources function and delivering a high-quality employee experience across the full employee lifecycle.
This role oversees core HR processes including onboarding, employee data management, reporting, HR systems, leaves, employee relations, offboarding, compliance support, and process improvement, while partnering across the business to build scalable, employee-centered practices that support Osanni’s growth.
The ideal candidate will bring strong operational discipline, sound judgment, attention to detail, and a service-oriented mindset - equally comfortable working strategically and hands-on in a fast-paced, evolving biotech environment.
You will play a key role in managing employee relations, responding thoughtfully to employee concerns, partnering with managers, and helping foster a fair, respectful, and values-aligned workplace.
What You Will Do
- Partner closely with the VP, People & Culture and senior leaders to shape and execute the People strategy, translating business goals into scalable talent, organizational, and employee experience priorities.
- Provide strategic oversight of the full employee lifecycle and associated HR operations, ensuring effective processes, strong controls, data integrity, and an employee experience that scales with organizational growth.
- Design and continuously improve onboarding and assimilation strategies that accelerate leader and employee effectiveness, strengthen culture, and support business readiness.
- Serve as a primary point of contact for employees and managers, providing clear, timely, and thoughtful guidance on HR policies, programs, and processes, and escalating issues appropriately.
- Manage employee relations by helping address workplace concerns, gathering and maintaining documentation, and partnering with leaders and employees to promote fair, consistent, and compliant practices aligned with Osanni’s values.
- Oversee leave of absence, accommodation, and other compliance-sensitive processes in partnership with Tri
- Net and external partners, ensuring legal compliance, operational rigor, and a high-quality employee experience.
- Establish and oversee standards for employee transitions, including voluntary and involuntary separations, restructures, and related change management activities, in partnership with Payroll, IT, Finance, and Legal.
- Lead HR reporting, people analytics, and workforce insights to inform strategic decisions, identify organizational trends and risks, and support compliance, audit, and board or leadership reporting needs.
- Drive continuous improvement of People processes, systems, and policies; identify opportunities to scale infrastructure, improve manager effectiveness, and enhance the employee experience across the organization.
- Own and manage the annual focal performance review process, including cycle planning, system configuration, communication, manager and employee guidance, and calibration support, ensuring a consistent, fair, and development-focused experience aligned with Osanni’s value and growth stage.
- Lead compensation planning and administration in partnership with the VP, People & Culture, including market benchmarking, salary structures, annual review cycles, equity and pay practices, and compensation recommendations that support pay equity and talent competitiveness.
- Lead broader People initiatives, including culture-building, engagement, and employee experience programs, in support of Osanni’s mission and growing team.
- Effectively manage multiple priorities in a fast-paced, evolving environment, ensuring deliverables are completed accurately, on time, and in alignment with organizational needs, while performing other related duties as required.
- Assess HR-related risk proactively and recommend practical, business-oriented solutions that balance compliance, culture, employee experience, and operational effectiveness.
What You Bring
- Bachelor’s degree preferred;
- HR certification (e.g., PHR, SHRM-CP) is a plus.10+ years of progressive Human Resources experience, including significant experience in HR business partnership, employee relations, performance management, compensation, and HR operations, with demonstrated scope at the Director level or readiness to step into a Director role.
- Demonstrated ability to handle highly sensitive and confidential matters with excellent judgment, executive presence, and a balanced, business-oriented approach.
- Deep employee relations experience, including managing complex and sensitive workplace matters, conducting or overseeing investigations, advising senior leaders, and driving sound resolution strategies.
- Strong compensation experience, including market benchmarking, salary planning, pay decision support, and familiarity with Radford or similar survey methodologies.
- Strong service orientation with a consistent sense of urgency and follow-through.
- Excellent communication, influence, and relationship-building skills, with the ability to build trust, challenge constructively, and operate effectively across all levels of the organization, including senior leadership.
- Highly organized, with the ability to manage multiple priorities, respond to urgent needs, and consistently meet deadlines.
- Demonstrated problem-solving skills and a continuous improvement mindset, with a track record of taking initiative and driving better processes.
- Proven ability to operate independently, influence without authority, and collaborate effectively with cross-functional stakeholders to deliver business-aligned people outcomes.
- Strong analytical capability and comfort using people data, metrics, and judgment to inform recommendations and decision-making.
- Strong interpersonal skills, including empathy, active listening, responsiveness, and adaptability to evolving employee and business needs.
- Experience with HRIS platforms required;
- Tri
- Net experience strongly preferred.
- Biotech, pharma, or medical device experience strongly preferred, including experience supporting regulated environments and scientific or technical employee populations.
- Experience in a venture-backed, high-growth startup environment is strongly preferred, with demonstrated success building scalable people practices amid ambiguity, rapid change, and resource constraints.
- The expected base pay range for this position is $215,000 - $240,000 plus bonus and comprehensive benefits.
- The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training.
We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.
We will provide an intellectually stimulating, collegial and fast-paced environment. If you are ready to be a part of building the future of transformative medicines, then we are excited to hear from you!#LI-hybrid
