Senior Molecular Technologist - Solid Tumor (1st Shift)

At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives.

We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting-edge molecular science and AI, we ask ourselves every day: “What would I do if this patient were my mom?” That question drives everything we do.

But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose.

Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins.

Position Summary

The Senior Molecular Technologist – Solid Tumor is responsible for performing various high complexity molecular techniques that include but are not limited to nucleic acid extractions and next generation sequencing (NGS). This position serves as a senior technical expert and resource within the molecular lab.

The Senior MT leads troubleshooting, method validation and assists in training efforts, ensuring operational excellence and data integrity across molecular workflows. This position works under the direction of the supervisor and follows standard laboratory procedures and policies.

Job Responsibilities

• Follows established laboratory protocols governed by standard operating procedures (SOPs).
• Performs molecular techniques with proficiency: nucleic acid extraction; quantification and normalization; PCR; DNA methylation analysis; and next generation sequencing (NGS) with consistency and precision.
• Operates and maintains liquid handling robots.
• Performs and oversees complex molecular testing and advanced troubleshooting.
• Maintains laboratory equipment, accessories and instruments used in clinical processing by performing routine maintenance.
• Leads training and mentorship of new and existing technologists.
• Prepares Corrective and Preventive Action (CAPA) documents for nonconformance events observed during the pre-analytical, analytical, and post-analytical clinical laboratory testing.
• Performs Proficiency Testing in a timely manner and submits results to supervisors.
• Collaborate with Quality and R&D teams to validate or implement new technologies, methods and equipment.
• Proficiency in the Laboratory Information Management (LIMS) tracking system to accurately perform and record day-to-day tasks.
• Represents the department in audits, investigations and cross-functional initiatives.
• Identifies and implements opportunities for continuous improvement, innovation and efficiency.
• Performs only those high complexity tests that are authorized by the laboratory director and require a degree of skill commensurate with the individual’s education, training, technical abilities and experience.
• Follow the laboratory’s procedures for specimen handling and processing.
• Adhere to and document all the laboratory’s quality control policies and activities as governed by FDA, CAP, CLIA, NYS and ISO regulatory standards.
• Perform instrument maintenance and procedural calibrations.
• Follow the laboratory’s established policies and procedures whenever test systems are not within the laboratory’s established acceptable levels of performance.
• Be capable of identifying problems that may adversely affect test performance or reporting of test results and either must correct the problems or immediately notify the supervisor, manager or director.
• Document all corrective actions taken when test systems deviate from the laboratory’s established performance specifications.
• Perform high complexity testing under the onsite, direct supervision of a general supervisor as defined in the CLIA regulations.
• Accepts other duties as assigned.

Required Qualifications

• Bachelor's degree in chemical, biological, clinical or medical laboratory science, or medical technology from an accredited institution.
• 10 years relevant molecular laboratory experience.
• Demonstrates mastery of molecular assay operations and QC systems.
• Proven ability to lead others and influence lab culture and technical standards.
• Proficient in Microsoft Office programs, such as Word, Excel, and Outlook. General working knowledge of internet for business use, and skilled in operating office equipment.

Preferred Qualifications

• Master's degree in chemical, biological, clinical or medical laboratory science, or medical technology from an accredited institution.
• Clinical laboratory experience preferred.
• Operates with high autonomy and professionalism.
• Technical authority with strong analytical judgement.
• Proactive, solution-oriented and collaborative.
• Mastery of laboratory safety procedures for biohazards and chemicals, as well as quality control procedures and regulations.

Physical Demands

• Will work at a computer that requires the use of copiers and PDF scanners.
• Visual acuity and analytical skills to distinguish fine detail. Ability to pass a visual color discrimination test.
• Manual dexterity to use common laboratory equipment and perform sterile techniques as required.
• Must possess ability to sit and/or stand for long periods of time.
• Must possess ability to perform repetitive motion.
• Ability to lift up to 30 pounds.
• May be required to handle and/or may have exposure to blood-borne pathogens, extreme temperatures, high noise levels, fumes and bio-hazardous material/chemicals including formaldehyde, xylene, Clorox bleach, DAB and alcohol, which emit fumes. Formaldehyde, xylene, and DAB are carcinogenic.

Other

• This position may require evenings/nights, weekends and Holidays.

Conditions of Employment: Individual must successfully complete pre-employment process, which includes criminal background check, drug screening, credit check ( applicable for certain positions) and reference verification.

This job description reflects management’s assignment of essential functions. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

Caris Life Sciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender, gender identity, sexual orientation, age, status as a protected veteran, among other things, or status as a qualified individual with disability.