Accounting Manager

About EGenesiseGenesis is a clinical-stage biotechnology company developing human-compatible engineered organs to address the severe global organ shortage. The Company’s proprietary genome engineering platform enables extensive, multiplex gene edits to remove key biological barriers, add protective human transgenes, and inactivate endogenous retroviruses.

EGEN-2784, a genetically engineered porcine kidney, is the Company’s lead program and is currently being evaluated in a multi-patient Expanded Access study at MGH. eGenesis is headquartered in Cambridge, MA.Position SummaryeGenesis, Inc is seeking a highly motivated Accounting Manager to execute the day-to-day functions during a pivotal period of growth.

Reporting to the Controller, this role will be responsible for all aspects of the monthly and quarterly close process. This highly visible role will use strong organizational skills and attention to detail to identify and implement operational decisions with accounting implications.

The ideal candidate combines strong technical GAAP knowledge with hands-on execution, thrives in a fast-paced and evolving environment, and is energized by building scalable processes from the ground up. This is a full-time role based in Cambridge, MA.

Primary Responsibilities

• Own the end-to-end financial close process, including general ledger, accounts payables, and accruals, delivering accurate and timely monthly, quarterly, and annual financial statements in compliance with U.S. GAAPAccount for R&D expenses, clinical trial accruals and prepaids, and CRO vendor arrangements, coordinating closely with clinical and operations teams to estimate accruals
• Help design, implement, and maintain internal controls over financial reporting (ICFR) in preparation for SOX compliance and public-company requirements
• Support preparation and maintenance of financial statements and supporting schedules, ensuring disclosures are accurate, complete, and audit-ready
• Manager Senior Accountant, fostering a high-performance team environment
• Design, implement, and maintain a robust internal control environment appropriate for a company operating under public company accounting standards
• Manage NetSuite as the system of record, partnering with FP&A on chart of accounts governance, reporting configuration, and process improvements

Basic Qualifications

• Bachelor’s degree in Accounting or Finance required;
• CPA preferred5+ years of progressive accounting experience, including public accounting and/or industry experience
• Public company accounting experience preferred, including demonstrated ownership of monthly close process under public company reporting timelines
• Biotech or life sciences industry experience required; familiarity with clinical-stage accounting (CRO accrual methodology, collaboration agreement) strongly preferred
• Hands-on proficiency with NetSuite required
• Excellent analytical, organizational, and communication skills, with strong attention to detail
• Ability to work independently, prioritize, and adapt in a fast-changing environment
• Base pay range for this job is $120,000 - $154,000.
• We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information.
• These tools assist our recruitment team but do not replace human judgment.
• Final hiring decisions are ultimately made by humans.
• If you would like more information about how your data is processed, please contact us.